The genes associated with trans-dominance of the influenza A cold-adapted live virus vaccine
Identifieur interne : 002004 ( Main/Exploration ); précédent : 002003; suivant : 002005The genes associated with trans-dominance of the influenza A cold-adapted live virus vaccine
Auteurs : Patricia Whitaker-Dowling [États-Unis] ; Rebecca Zvolenski [États-Unis] ; Julius S. Youngner [États-Unis]Source :
- Virology [ 0042-6822 ] ; 1991.
Descripteurs français
- KwdFr :
- Animaux, Cellules cultivées, Embryon de poulet, Gènes viraux, Interférence virale, Passage en série, Phénotype, Protéines virales (génétique), Réplication virale (génétique), Température, Vaccins antiviraux, Vaccins atténués, Virus de la grippe A (croissance et développement), Virus de la grippe A (génétique).
- MESH :
- croissance et développement : Virus de la grippe A.
- génétique : Protéines virales, Réplication virale, Virus de la grippe A.
- Animaux, Cellules cultivées, Embryon de poulet, Gènes viraux, Interférence virale, Passage en série, Phénotype, Température, Vaccins antiviraux, Vaccins atténués.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Viral Proteins.
- genetics : Influenza A virus, Virus Replication.
- growth & development : Influenza A virus.
- Teeft :
- Allantoic fluids, Animals, Cells, Cultured, Chick Embryo, Clonal analysis, Clone, Embryonated, Embryonated eggs, Footnote table, Gene, Gene reassortant, Gene reassortant viruses, Gene reassortants, Genes, Viral, High proportion, Infection, Influenza, Maassab, Mdck, Mdck cells, Parental virus, Phenotype, Progeny, Progeny virus, Protein synthesis, Protein synthesis phenotype, Reassortant, Reassortant clones, Reassortant virus, Reassortants, Relative migration positions, Replication, Serial Passage, Single gene reassortant, Single gene reassortants, Temperature, Vaccine, Vaccines, Attenuated, Viral, Viral Interference, Viral Vaccines, Virus, Youngner.
Abstract
Abstract: Segment 7 (M) of the cold-adapted live influenza A virus vaccine plays a primary role in the ability of this virus to interfere with the replication of wild-type influenza A viruses. This conclusion is based on several lines of evidence. Single gene reassortant viruses derived by crossing influenza A/Ann Arbor/6/60 (H2N2) cold-adapted donor virus with an epidemic wild-type strain, A/Korea/1 /82 (H3N2), were tested for their ability to interfere with wild-type parental virus in the Madin-Darby line of canine kidney cells and embryonated eggs. It was apparent in both hosts that the single gene reassortant carrying segment 7 (M) derived from the cold-adapted virus was dominant over wild-type virus. Additional confirmation of the role of segment 7 (M) in trans-dominance of the cold-adapted vaccine virus was derived from the analysis of reassortants produced by mixed infection by a wild-type virus and its cold-adapted reassortant vaccine strain. After three serial passages, the virus yield contained a high proportion of reassortants carrying segment 7 (M) of the cold-adapted parental strain. When used in mixed infections, these reassortants were dominant over the replication of the parental wild-type virus.
Url:
DOI: 10.1016/0042-6822(91)90011-Y
Affiliations:
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Le document en format XML
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This conclusion is based on several lines of evidence. Single gene reassortant viruses derived by crossing influenza A/Ann Arbor/6/60 (H2N2) cold-adapted donor virus with an epidemic wild-type strain, A/Korea/1 /82 (H3N2), were tested for their ability to interfere with wild-type parental virus in the Madin-Darby line of canine kidney cells and embryonated eggs. It was apparent in both hosts that the single gene reassortant carrying segment 7 (M) derived from the cold-adapted virus was dominant over wild-type virus. Additional confirmation of the role of segment 7 (M) in trans-dominance of the cold-adapted vaccine virus was derived from the analysis of reassortants produced by mixed infection by a wild-type virus and its cold-adapted reassortant vaccine strain. After three serial passages, the virus yield contained a high proportion of reassortants carrying segment 7 (M) of the cold-adapted parental strain. When used in mixed infections, these reassortants were dominant over the replication of the parental wild-type virus.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region><settlement><li>Pittsburgh</li></settlement><orgName><li>Université de Pittsburgh</li></orgName></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Whitaker Dowling, Patricia" sort="Whitaker Dowling, Patricia" uniqKey="Whitaker Dowling P" first="Patricia" last="Whitaker-Dowling">Patricia Whitaker-Dowling</name></region><name sortKey="Youngner, Julius S" sort="Youngner, Julius S" uniqKey="Youngner J" first="Julius S." last="Youngner">Julius S. Youngner</name><name sortKey="Zvolenski, Rebecca" sort="Zvolenski, Rebecca" uniqKey="Zvolenski R" first="Rebecca" last="Zvolenski">Rebecca Zvolenski</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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